I can,t understand exactly what you ask about ? but the difference between them is.... "Have you ever been to Italy?" ( positive question) the Negative answer is (No , i have never been to Italy) and the positive answer is ( yes, i have been to Italy) but have you never been in Italy? the positive answer is ( No, i have never been .....) and the negative answer is (yes, i have been ....) this is called (Negative question ) i hope i could answer your question :)