They are both possible, but the context is different. The normal form is 'Have you ever been to Italy?' When you ask this, it is a simple question, and you have no idea whether the person has been to Italy or not. However, let's imagine that you meet someone in New York who looks Italian, sounds Italian, and speaks perfect Italian. This person then tells you that they have lived all their life in the USA. You are amazed, and you would say: 'Really? Have you never been to Italy? That's incredible!' I hope that helps!

I can,t understand exactly what you ask about ? but the difference between them is.... "Have you ever been to Italy?" ( positive question) the Negative answer is (No , i have never been to Italy) and the positive answer is ( yes, i have been to Italy) but have you never been in Italy? the positive answer is ( No, i have never been .....) and the negative answer is (yes, i have been ....) this is called (Negative question ) i hope i could answer your question :)

Thank you!

I think what you're asking is how to say "Have you ever been to Italy?"