Thank you for helping me. 谢谢您的帮助。 What's wrong with you ？ 你怎么了？/你遇到什么麻烦了吗？

Don't follow Eric's你有毛病呀?/你（他妈）有病呀？these words are very rude and unpolite——and is not the meaning for 'What's wrong with you' You can say these instead: 你怎么了？ nǐ zěnme le （你：nǐ in rising tone and followed zěn,both in rising tone,so read it as ní） 发生什么事情了？ fāshēng shěnme shìqíng le for thanks, theirs are OK. 多亏了你帮忙 duō kuīle nǐ bāngmáng 谢谢你的帮助 xièxiè nǐde bāngzhù 感激不尽 gǎnjī bú jìn

thank you for helping me: 谢谢你帮助我。 thanks for your help: 谢谢你的帮助。 those are translations and in daily life what do we say? maybe: 谢谢您帮忙/多亏您帮忙/您辛苦了，谢谢！ What's wrong with you: 你怎么回事？/你有毛病呀？/你（他妈）有病呀？ (with an angry tone)

The second part: 出了什么问题你 chūle shénme wèntí nǐ Or simply: 你怎么了 nǐ zěnmele

Hello Eisya, I know the first part : Thank you for helping me 谢谢你的帮助 xiexie ni de bangzhu