last time of editting I hope this would be the last time of this writting. it seems that i cannot continue. The increasing interest in cancer stimulate my strong desire for the involvement in the research of this field. During my undergraduate period, I selected the dissertation project that focused on investigating the crosstalk between glycan structures and cancer disease progression, which gave me a taste of cancer research. To obtain professional training in this field, I took the MSc cancer programme at University College London where I acquired a basic knowledge of cancer biology and got a better understanding of the current state of cancer research in different fields, such as epigenetic modifications, cell cycle regulation and minimal residual disease. The MSc dissertation project provided me with scientific training and new insights into how scientific research is conducted. I mastered useful experimental skills including cell culture, RT-PCR, western blotting and IF microscopy, as well as basic analytical skills. More importantly, I am capable of solving the problems through analysing phenomena and performing assisted experiments after the three-month internship at UCL cancer institute. These academic and practical experiences prepared me for a PhD position. I am particularly fascinated in the study of the deregulation of APOBECs which potentially have the mutagenic effects on the host genome in HPV-associated tumors. This exciting work at Kent university will possibly validate its potential carcinogenicity and explain the link between HPV infection and A3-mediated tumorigenesis. I am highly motivated to be involved in this promising study at Kent university. I am convinced that this programme will be the most ideal platform from which I can acquire comprehensive training and achieve my career objective of becoming a researcher.