Nico, that's a very interesting question, if in the conversation the noun is implied, we would make an accordance with the gender (article, pronouns, adjectives)
"¿Te gustan estas frutas? -¡Sí, esas son mis favoritas!"
As for possessive pronouns, remember we have a neutral variation when we are talking about abstract concepts, when we're not specifying what thing we are talking about...
"Esto es muy difícil"
In this example, we don't know exactly what "esto" is, if we specify, then we make an accordance:
"Esta situación es muy difícil"
Hope it helps!