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To evaluate the epidemic prevention and control effect By analyzing the changes of novel Coronavirus Pneumonia in Henan Province so that we can provide the theoretical basis for optimizing the epidemic prevention and control strategy .From the People's Republic of China and Henan Provincial Health And Health Commission's official website published in the NCP outbreak bulletin, select the epidemic change data from January 21 to March 31, 2020, establish the epidemic trend related chart of COVID-19 in Henan Province, to carry out epidemiological descriptive analysis. Combined with the chart and preliminary analysis of the data, it can be seen that the epidemic prevention and control measures in Henan Province played a great role in time to avoid the rapid spread of the epidemic. Henan Province for the COVID-19 outbreak, under the guidance of government policy, combined with the actual prevention and control measures taken in the province timely and effectively limited the spread of the epidemic, and achieved significant results, the outbreak in late February, the outbreak improved, but Henan Province's large population, still need to pay close attention to the movement of the returned migrant population and the incidence of the situation in various regions, and targeted measures to strengthen prevention and control.