Presentation 8316048 <Back ground> Hello, my name is Yu Sugita, and today I'd like to talk about Richard Axcel, Linda B-Buck and his work to find the mechanism of sence of smell. Smell is one of the five senses. Richard Axel is neuroscientist in the United States and professor of columbia university. He was interested in how the brain interprets olfaction. Linda-B-Buck is biologist in the United States. She was interested in how pheromones and smells were detected by the nose and transmitted to the brain. <Reserch questions> How is smell transmitted to the brain. <Methods and data> In 1991, Linda Buck, Richard Axel released a monngraph. 1:To identify molecules in the olfactory, he using PCR of gene superfamily. 2:Cloning the Gene family. 3:Find the protein sequence of numerous, olfactory -specific members of the seven transmenbrane. <Conclutions and Future Reserch> Their works found a large gene familyof olfactory system, comprised of some 1000 different genes. And they got the 2014 nobel prize in Medicine and physiology. Thank you for listening.