Hi Camila.
I think Make is for producing, constructing, creating or building something new.
It is also used to indicate the origin of a product or the materials that are used to make something.
DO is used when talking about work, jobs or tasks. Note, they do not produce any physical object.
DO is used when we refer to activities in general without being specific. In these cases, we normally use words like thing, something, nothing, anything, everything etc.
Follow this link to see more details: http://www.vocabulary.cl/Intermediate/Do_Make.htm
Bye.