Regional accents do make a difference, but in the US, I rarely hear anyone's accent so heavy that I can't tell the difference. I only remember one instance with a guy from Maine.
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June 6, 2016
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Corrected
0 voted
May 23, 2016
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Answered
"Run down" can mean to chase and catch someone or something. It can mean to deplete, like "You are going to run down the battery. It can mean you are tired. "I am so run down." It can means to find information about something. "Run down the facts about the case."
"Run out" can mean to deplete or use something up. "We are going to run out of sugar." It can mean to go get groceries or something else. "Run out and get some sugar."
These are some uses.