2/12/17 You have to overcome your fear. If you scare something just do it and when you finish it. It's amazing. I'm afraid of heigh but I took a ride on the Ferris giant wheel. It was wonderful views from the wheel. After that, I still afraid of heigh but I love to see from bird's eye view.

29/11/17 Some people who have never been single, they will never know the happiness of freedom and independence to live their lives. Some people who have never been a couple, they will never know the happiness and warm heart that have someone who always be with you. However, it has a double-edged sword. You should balance your happiness do not put your happiness in others hands because at last no one can live with you forever. You must stand and strong by your self.

28/11/17 Almost 10 days that I didn't write my diary but now I'm back. After I watching music video of Ed Sheeran which was Perfect. I was really happy and feel good with this video. It was positive and romantic moment of couple. I'd love to see people love and good take care each other. It reveals that people still have human kind and the world is not too bad to live with happiness. Love is beautiful

13/11/17 The hidden reason that I move to study abroad because I broken heart. We were friends from school, dated about 1 year and became good friends. Seven years later, he came back to me. We spent long weekend together and he said that he still loved me for the past 7 years. Unbelievable, during last 7 years he had girl friend and the day that he told me he remained relationship with her. He said that he loved me but he didn’t deserve me because I beyond on him. It was ridiculous. If you love someone enough, you will do anything to beside her, not just say good words but no action. He was such a selfish guy and though that I was his toy but I though I had value enough to be an only one girl not just some girls of a man. So I decided to step away from him and improve my self to keep and expand the space between us. If he treated me like a toy, I would be the expensive toy that he can’t pay.

Report The results of F1, in which the concentration 4% and feed rate was 3, indicated that the particle size was 3 nm and distribution was 2.3 nm. For F2, which has the concentration 3% and feed rate was 5, the results showed that particle size and distribution was 1 nm and 1.2 nm, respectively. At higher feed rate can generate the large particles. Because of increasing feed rate, lowers the outlet temperature and thus increase the temperature difference between the inlet and outlet temperature. Feed rate also determines the duration of the process for which one expose the high temperature. An increase in feed rate cause reduction in particle size. Corresponding to the concentration, the higher concentration of spray solution produce enlarge particles.

17/10/17 I feel uncomfortable with somebody. It's a bad way. In front of me, he looks nice but many scenarios make me feel like I was betrayed. Many it just popped in my head and I'm over thinking, but in fact there is nothing. Do not compare your weakness with others strength.

In conclusion The abilities of nanoparticles can overcome the major challenges associated with oral route of administration: mainly poor solubility, stability and biocompatibility of drugs by protecting the drugs and facilitate them into the body. Otherwise, the particles toxicity as obtained in oral delivery should investigate and study further.

Nanotechnology Nanotechnology is related to pharmaceutical science as applied to medicine, mostly base on nanoparticles. In general, can be used drug delivery to reduce toxic and harmful effects of drugs while maintaining therapeutic effects, greater safe and biocompatibility, improve bioavailability and solubility. There are several methods of nanoparticles for drug delivery to enter the body. For instance, inhalation, ingestion, intramuscular injection, transdermal delivery, intravenous. Among of these methods, oral delivery is most preferred due to has a significant impact on the treatment of many diseases and various of advantages over other routes including patients convenience and compliance Eventhough, oral administration has many benefits, there are many obstacles for delivering from external barriers in the gastrointestinal tract (GI) that are designed to break down and exterminate the foreign particulate such as extreme pH, enzymes degradation and poor intestinal epithelium permeability limit adsorption. Particularly, poor water-soluble drug, peptide and protein drugs.