Yes you can.. in everyday English .. I walked upto the pub yesterday. Next time you visit we will take a drive up to Scotland. Interesting point .. in England we always say go up to London even though it is south

Can you give us a sentence as an example so that we know exactly how you mean that?

Usually, as far as travel goes, we use 'up to' to indicate motion North and 'down to' for motion South. 'Up to' can also be used for small distances to indicate up to a place, but no further. "Drive your car up to the starting line and wait for the signal to start." It can also be used for altitude. "The plane went up to 13,000 meters and leveled off."