First neither are questions. They are both statements. Unless you put some inflection into the last word. Then they would mean the same thing. Is this good, OK, with you? So context is the key. The main difference used as statements would be whether you are holding what you are giving or are able to hold it. Go would tend be indicating direction, the motion of giving or the motion towards what the person is going for, like if you are dropping somebody off. Are is a form of is so it is more general, in the presence of the person.