about your title, it should be 这句话，you missed one part of 话。 WuHuan asked him on purpose:"how what ?not good at all, how would you wish me to do? 怎么样 in different contact has different meanings. It can be geeting people like"你怎么样，你今天怎么样，你工作怎么样"，怎么样also could use for ask about opinions and suggestion , like 这个怎么样？ 怎么similar like english how.

“什么怎么样？ = What do you mean "how"? 不怎么样！ = Not "how" = None of your matter 你希望我怎么样呢？ = What's your hope for my "how"? = What do you expect of me?

Wu Huan asked him directly “what do you want to say? It’s none of your business!what do you want me to do?” (I tried my best 😂😂

rhetorical question, ...it seems wuhuan is reluctant to answer

Your title should be: 这句话是什么意思. I'm a Chinese, and I know the meaning of that sentence, but excuse me, I can't translate it in English completely, because It's hard for me.