"No ensucies la casa!" Don't mess up the house. "Ella siempre me ensucia el celular cuando lo usa" She always screws up (OR messes up) my cell phone when she uses it. (If it doesn't work./Si no functiona.) She always gets my cell phone dirty when she uses it. (If there is actual dirt on it./mugre) "El nunca ensucia el jardin" He never makes a mess of (OR litters) the garden.

Also: to soil, to dirty, to litter, to defile, to besmirch, to pollute, to foil.

"To mess with". "She always messes with my cell phone when she uses it./He never messed up the garden."

"No ensucies la casa!" Don't make a mess in the house! "Ella siempre me ensucia el celular cuando lo usa" She always messes up my phone when she uses it. "El nunca ensucia el jardin" He's never made a mess in the garden.