In this sense 'vibe' is being used to describe each persons general personality and also the way they may react in different situations. So another more basic way to say the sentence would be 'you and he are different types of people' or 'you and he act differently'. Is this a sentence you have read or created yourself? Could you give me the sentences that are before and after this one. It will help me with context. I hope this helps and let me know if you have any other questions.

I would say that 'you and he vibe differently' could mean various things. It's even quite likely that it's a poor choice of words. Please provide more context, for example the sentences before and after this quote. Without added context, my first assumption would be that it either means ''you and he have a clashing sense of style'' or ''you and he don't communicate smoothly'' - see how different the interpretations can be! Please add more context if you want a confident, precise explanation.