"Make" is a synonym with "create". "Do" is just a general word to describe any action. There's no overlap in their meanings (well, "do" technically overlaps with every single verb by definition), but they're both very common verbs, so they're common in set phrases in which they can't be interpreted literally. E.g. "To make a bed" literally means "to construct a bed", but it's also a set phrase that means "to neaten and tidy a bed's pillows and sheets".

Thank you! It's helpful.

here an example: Hey! i'm looking to your youngest sister, "do you know where she is?" verb "do" is mostly used in question. like "what are you doing here?" "do you remember when is her birthday?