Depends on how you look at it. In America, collective nouns are normally treated as singular. Whereas in Britain (& Ireland) it often depends on whether you see the noun as a unit or as individuals. So if you see your family as a whole unit, then it is 'is'. But if you see them as individuals (i.e. all my family), then you use are. But as I mentioned in my comment, you need to include 'the'. My answer would be: 'My family are from the U.S.' is the correct statement as it relates to all my family and 'My family is American' as it refers to family being singular.

Say "family is". The word is a group noun, but countable, so we are forced to use singular here.

Students need to know precisely how to answer test questions. In a lot of countries, there is only one correct answer. The future of students is on the line. The test grader will not pause to inquire intent. Countable singular noun requires singular verb, period.

It should be: My family are from the U.S.

first one is correct