When something "get's to" a person, it means that it irritates a person. If "Life get's to You" it may mean you are disturbed by all of it and you like none of it. If something "Just gets to you" in may mean that their is little more explanation for how bad it bothers you. Therefore, this person may be in the loony ben )a hospital for mental problems) or they may have tried to commit suicide. If "life just got to him" it sounds very bad. "I guess life just got to him, I can't believe he ran away. We might never see him again. I did not realize we wee so hard on him."