En este caso, lo más correcto sería decir: “ Qué hay de nuevo ? “ . Es una pregunta introductoria a una conversación, una pregunta “rompe hielo” . In this case the correct xpression should be : “ qué hay de nuevo? “ . Its an introduction question that break the ice.

I had a flash card in Anki that said this means What is up or something like that. I didn't think it was true so I asked here. I'm glad my suspicion was right!

In Argentina, we neither say "Cuál es nueva?" as It would mean "What's up?", we say "¿Cómo andás?" or "¿Cómo estás?" Instead "¿Cuál es nueva" you can say "¿Qué hay de nuevo?" But it isn't so popular.

Well, here in Spain we don´t say that. -When you´re talking with someone who is not so close to you, then you say "¿Qué tal estás?" -But when you´re talkin with a friend, we say "¿Qué tal?" As you can see, in the second one we remove "estás" but is only to make the phrase shorter.

Thanks Alfredo!