아무튼 말이야 자기는 => Anyway, speaking of you, (honey), ... (if it's a start of a full sentence) => Anyway, you (dear) are something. (if it's in isolation) 아무튼 말이야 is hard to translated exactly. "anyway" is probably close enough. 자기 in 자기는 can be an endearing reference like "honey", etc. but it is used quite often as a simple "you" too. 너 sounds rather direct and has a nuance of treating the person as younger or less important than oneself, so some similar aged friends and couples like to use 자기 (oneself, yourself) instead of 너 until they are really close. In fact, this is how 자기 acquired the sense of "honey", because of heavy usage by dating couples who don't feel comfortable with 너 (some couples avoid 너 even after they go steady or sometimes even beyond marriage). So even between lovers and spouses, 자기 means "you" first, so translating 자기 as "you" is almost always correct.