The best place to live and work in the US depends on a few different factors. Do you prefer living in or near a large city? What type of job are you trying to get? If you are just looking for the area with the highest job availability and the lowest cost of living, I recommend the Midwest. States such as Nebraska, Iowa, and Kansas often have many jobs available. These places also have many apartments and homes available for rent. I hope that this helped! :)