"She is gone" and "she has gone" are both correct, but only "he has spoken" is correct. The reason is that "gone" can refer both to a state and an action (the state of being gone, and the action of leaving). However, a person can perform the act of speaking but cannot be the "state of speaking" (as would implied the incorrect sentence "he is spoken.")

you can say both she has gone and she is gone depending on the context but it's he has spoken. Because when you say spoken it is in the past tense so you need to use has and you would say he is speaking if it is in the present tense