Gut bacteria can stop drugs from working Normally, most research has focused on how their gene controls their body response to drugs. However, the bacteria and microbes inside our body can determine whether a drug work or not. Scientist stated that different people can have different results base on the same drug. However, there’s also a negative effect because microbes sometimes turn drug into useless or toxic compounds. For example, bacterial enzymes remove the group called glucuronidate and turn the drug into toxic. To further prove the assumption, scientists collected faecal samples from 20 healthy people. The scientists found 4 of the samples contain high levels of toxic, which means that different people may have a different microbiome in their body. It’s a nice step to know how gut bacterial enzymes interact with drugs and the microbiome’s effects could be far-reaching. There are some examples of gut bacteria that seem to modify drugs. However, it’s still not clear that how many gut bacteria vary among different people. There is another HIV-prevention drug that is ineffective in women because of the type of bacterium, though scientists still don’t know the procedure. Therefore, some clinicians can screen people’s microbiomes first and know whether a drug will work for them or not. If the gut microbiomes are problematic, the doctor could use enzyme inhibitor to prevent from the problem. As usual, it still has a long way to go for physicians to prescribe such therapies routinely.