Nanotechnology Nanotechnology is related to pharmaceutical science as applied to medicine, mostly base on nanoparticles. In general, can be used drug delivery to reduce toxic and harmful effects of drugs while maintaining therapeutic effects, greater safe and biocompatibility, improve bioavailability and solubility. There are several methods of nanoparticles for drug delivery to enter the body. For instance, inhalation, ingestion, intramuscular injection, transdermal delivery, intravenous. Among of these methods, oral delivery is most preferred due to has a significant impact on the treatment of many diseases and various of advantages over other routes including patients convenience and compliance Eventhough, oral administration has many benefits, there are many obstacles for delivering from external barriers in the gastrointestinal tract (GI) that are designed to break down and exterminate the foreign particulate such as extreme pH, enzymes degradation and poor intestinal epithelium permeability limit adsorption. Particularly, poor water-soluble drug, peptide and protein drugs.