a little bit of science
According to the data about structure of the free enzyme and its complexes with DNA, in the enzyme-substrate complex, the DNA is bent by 70° in the place of the damaged nucleotide position.
Amino acid residues are built in the formed DNA cavity. The structural data suggest that DNA binds in a channel of the enzyme having a single positively charged His-270 residue, which forms a hydrogen bond with the 5′-phosphate group of the damaged nucleotide.
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a little bit of science A Little Bit of Science
According to the data about the structure of the free enzyme and its complexes (?) with DNA, in the enzyme-substrate complex,.The DNA is bent by at 70° in the place of the damaged nucleotide position.Amino acid residues are built in the formed DNA cavity. The structural data suggest that DNA binds in a channel of the enzyme, having a single positively charged His-270 residue, which forms a hydrogen bond with the 5′-phosphate group of the damaged nucleotide.
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