writting practise 1 disease progression model development in current quantitative research Abstract: As a new trend in model-based drug development, disease progress model is a description of the dynamic changing within disease status over time. It is rapidly becoming an important method to study how the drug action on disease. To make the treatment appropriate to a specific patient, the trend of the individual disease changing information can be predicted by the research of disease progress model. We summarized some disease progress models and drug action mode which have been successfully used in recent years and discussed the prospect of modeling and simulation of disease progression model.