One sentence... not sure

There are a few issues here. (Leaving aside that physics is not a hindrance but rather a science of sheer beauty!)

The sentence is a bit awkward and it's difficult to understand your exact meaning.

A hindrance is something that obstructs you. Physics can't do that; it just "is". Some people can understand it easily, some people can struggle with it. It can be the biggest challenge for you if you don't feel an affinity for the subject. Alternatively understanding physics (as opposed to physics itself) can be the biggest obstacle that you had in completing your university studies.

"I was bound to"... in what sense? Was it a prerequisite of the degree that you were doing? If you had no choice but to do physics as part of your degree then in that sense you were bound to it, but usually (not always) there are alternative paths to a degree.

Also I'm not sure about your intention when you say "career"; if you're a student, it's stretching the definition of "career" to use the word to refer to your degree course. Your career begins after that. if you are working in a university as a professor, on the other hand, then it's a career but I can't see how physics would be something that you are bound to.

What I think you may mean is:

Understanding physics was the biggest challenge I had to overcome in my university course.