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The aim of this study was to investigate the dissolution of ulexite mineral in water saturated with carbon dioxide at different pressures. Reaction temperature, CO2 partial pressure, stirring speed, solid/liquid ratio and ulexite particle size were selected as parameters on affecting the dissolution rate of ulexite. As a result of experimental studies it was found that the dissolution rate increased by the increase of the reaction temperature and CO2 partial pressure, and decreased with the particle size and the solid/liquid ratio. No effect of stirring speed was determined on the dissolution rate. To determine the effects of parameters and model kinetic equation, homogeneous and heterogeneous reaction models were used, and Avrami model was found to be the best model expressing the process of dissolution. The activation energy of this dissolution process was found to be 21.36 kJ/mol. Analysis of variance (ANOVA) was performed to examine the effect of parameters on the fraction of dissolution. According to results, the effectiveness of parameters; the reaction temperature, the particle size of ulexite, the solid/liquid ratio and the total pressure was determined respectively. The speed of stirring was determined had to have no effect. The interaction of reaction temperature and reaction time has very significant influence on dissolution rate.