This can be a difficult question to answer. As an American, I have no problem understanding this phrase, but I can see how others can have trouble. This question is a rhetorical question (if you don't know what rhetorical is, a rhetorical question is one that does not require an answer, or is not meant to be answered). There are two ways that this phrase can be used: 1) Sincerely. If someone is really concerned about someone's health, they may ask what is making them feel bad. This form is less common, as the phrase is often used when someone is shocked or angry. 2) In shock, frustration, or anger. If someone is acting very weird, they may be asked, "What's wrong with you?!" This phrase implies that the way they are acting is not normal. I see this phrase to have a very literal meaning. It means the same thing that it asks, although most of the time, whatever is 'wrong' is more emotional than physical. Does this explanation make sense? Or should I explain it more?

Without trying to say the obvious...... "What's wrong with you?!" is usually said by one character when they don't agree with the actions or words of another character. If you ask a child not eat all the chocolate in the box but they do you will say "What's wrong with you - I told you not to eat all the chocolate!?" for example. Hope that helps.

"What's wrong with you?" is used when the speaker is certain that you are unwell or acting in an unusual way, and wants to know the precise cause. It can also be used to express frustration at unreasonable behaviour. "What's wrong with you? Why won't you do what I tell you?" "What's wrong?"Are you ok?".