I think it's better to write "Fortune is good to those who know how to make good use of it" .

English nouns don't have genders and "fortune" is not an animate nouns, but an abstract word, so you can't use the pronoun "her" to refer to "fortune", because in this case you would be assuming that "fortune" is a feminine noun.

  So, I would use "it" in this case, because "fortune" is a neuter noun and don't have gender in english.

crystal的小作文: May 08, 2010

Fortune is good to those who knows how to make good use of her. Yeah, we often wanna want a lucky star around us, but it seems what we should do is to grassip those important things which also bear out they show themselves to be are valuable.  Maybe they are right up our alley hehe...

You had a very long sentence there, Crystal, so I divided it into 3 smaller sentences.
Also, 'wanna' is a slang word meaning 'want to', not to be confused with 'want a'.

crystal的小作文: May 08, 2010

Fortune(幸运) is good to （him ）（不必）who knows how to make good use of her,yeah,we often wanna lucky star to be  around us,but it seems what we should do is to grassip those important which also bear out they are valuable,maybe they are right up our alley hehe...

不好意思，能力不足，只能改这么多。希望对你有帮助